Carbohydrate sensing in water is very challenging. In collaboration with the Kharlampieva group at UAB, Xiaoli Liang in our group was recently able to improve the solubility of boronic acds in water and the affinity of their interaction with carbohydrates, by connecting phenylboronic acid moieties to a hydrophilic poly(methacrylic acid) polymer to generate a water-soluble copolymer that can be used as a supramolecular receptor. Coupled with an indicator displacement assay, this polymer was able to differentiate both monosaccharides and disaccharides in neutral aqueous solution.
This work was recently published in ACS Applied Polymer Materials where it was featured on the cover (left).
This work was recently published in ACS Applied Polymer Materials where it was featured on the cover (left).
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